March 7, 2025: Who doesn’t want to be slim and fit? Societal beauty standards, media representation, and cultural norms often emphasize the importance of physical appearance, leading many to strive for a slender physique.

But if you’re not being able to lose weight, science says some genes might be the culprit.

One of the most significant discoveries is the DENND1B gene, which has been linked to obesity in    humans and even in Labradors. Researchers found that individuals carrying the DENND1B gene variant had around 8% more body fat than those without it. This gene affects the brain’s energy balance pathway, making it harder for individuals to control their appetite and weight.

Other genes, such as Brain-Derived Neurotrophic  Factor (BDNF) and Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2), have also been associated with obesity. These genes play a crucial role in regulating appetite, metabolism, and energy balance.

By understanding the genetic components of obesity, researchers hope to develop more effective treatments and prevention strategies.